Allied Journal of Medical Research

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Allied Journal of Medical Research 44 7897 074717

Journals Of Developing Drug

 

The use of carbon monoxide gas (CO) as a therapeutic agent has already been tested in human clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of varied human diseases. However, the utilization of gaseous CO faces serious obstacles not the smallest amount being its well-known toxicity. to completely realise the promise of CO as a therapeutic agent, it's key to seek out novel avenues for CO delivery to diseased tissues in need of treatment, without concomitant formation of elevated, toxic blood levels of carboxyhemoglobin (COHb). CO-releasing molecules (CO-RMs) have the potential to constitute safe treatments if CO release in vivo are often controlled during a spatial and temporal manner. it's already been demonstrated in animals that CO-RMs can release CO and mimic the therapeutic effects of gaseous CO. While demonstrating the principle of treatment with CO-RMs, these first generation compounds aren't suitable for human use. This tutorial review summarises the biological and chemical behaviour of CO, the present status of CO-RM development, and derives principles for the creation of subsequent generation of CO-RMs for clinical applications in humans.

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