Asian Journal of Biomedical and Pharmaceutical Sciences

Asian Journal of Biomedical and Pharmaceutical Sciences 44 7897 074717

Extracellular Proteases Peer-review Journals

Proteases (peptidases, proteinases, or proteolytic enzymes) are enzymes which breaks peptide bonds between amino acids of proteins. The process is called proteolytic cleavage, a very common mechanism or process of activation or inactivation of enzymes especially involved in digestion or blood coagulation. The field of protease research is enormous. Barrett and Rawlings (2003) estimated that approximately 8000 papers related to this field are published each year. Protease constitutes one of the most important groups of industrial enzymes accounting for about 60% of the total worldwide enzyme sales. (Olajuyigbe & Ajele, 2005; Nascimento and Martins, 2004; Beg and Gupta, 2003; Ellaiah et al., 2003).

Bacterial proteases are the most significant, compared with animal and fungal proteases and among bacteria, Bacillus species, as in Bacillus subtilis are specific producers of extracellular proteases (Olajuyigbe & Ajele, 2005).Extracellular proteases are important for the hydrolysis of proteins in cell-free environments. Therefore the production of extracellular proteases are taken in consideration for this project.

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