Journal of Clinical and Experimental Toxicology

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Journal of Clinical and Experimental Toxicology 44 7897 074717

Environmental Toxicology Innovations

Toxicology Changes within the normal redox state of the cells can create  toxic effects in the course of the assembly of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Oxidative stress from oxidative metabolism causes base damage, also as strand breaks in DNA. Base damage is usually indirect and caused by reactive oxygen species (ROS) generated however, excess ROS production can damage lipids, DNA, and proteins which may cause necrobiosis. In accumulation, to that the cellular antioxidant defenses may decrease during aging which goes up in age-related increase of ROS and oxidative stress. Excess ROS also can activate the proinflammatory signaling pathways and therefore the release of multiple inflammatory mediators, like cytokines, chemokines, eicosanoids, et al. . Therefore, oxidative stress is implicated in the pathogenesis, development, and progression of a sustained inflammatory state.

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