Archives of General Internal Medicine

Chronic Hepatitis C

Chronic hepatitis C means the major causes of chronic liver disease through worldwide and provides a variable organic history ranging from minimal modifications to advanced fibrosis and cirrhosis and also its difficulties, similar to development of hepatocellular carcinoma. The aim of this paper was to review the epidemiology and management of chronic hepatitis C. The management of chronic hepatitis C has been challenged by the use of noninvasive methods to stage liver fibrosis as an alternative to liver biopsy and the high cost of new interferon-free antiviral treatments. Moreover, the need of cost-effectiveness analysis in hepatitis C and the recent changes in treatment protocols were discussed.

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