Hematology and Blood Disorders

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Hematology and Blood Disorders 44 7897 074717

Autoimmune Uveitis Journals

The uvea represents the vascular organ of the eye and it is composed of the iris, ciliary body and, choroid. Autoimmune uveitis (AU) is an inflammatory process of these uveal components due to an autoimmune reaction to self-antigens or caused by an innate inflammatory reaction secondary to an external stimulus. It can present as an isolated entity or associated with a systemic autoimmune or autoinflammatory disease. Because of its proximity to other parts in the eye, inflammation can cause damage to ocular layers such as the retina and structures like the vitreous body and optic nerve. This compromise is considered one of the principal causes of preventable blindness around the world .

Eye inflammation can be the initial presentation in many autoimmune diseases (AD) manifesting as conjunctivitis, episcleritis, or scleritis. Diseases such as rheumatoid arthritis (RA) systemic lupus erythematous (SLE) are commonly associated with these type of manifestations. On the other hand, anterior uveitis typically appears as the initial manifestation in autoinflammatory diseases such as ankylosing spondilitis (AS) . There is a clear association described with the HLA-B27 positivity and a higher risk of presenting recurrent anterior uveitis in AS .

 

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