Journal of Biochemistry and Biotechnology

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Journal of Biochemistry and Biotechnology 44 7897 074717

ARACHIDONIC ACID ARTICLE

Arachidonic acid (AA, sometimes ARA) may be a polyunsaturated omega-6 carboxylic acid 20:4(ω-6), or 20:4(5,8,11,14).[2] it's structurally associated with the saturated arachidic acid.
Arachidonic acid may be a polyunsaturated carboxylic acid present within the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of membranes of the body's cells, and is abundant within the brain, muscles, and liver. striated muscle is an especially site of arachidonic acid retention, accounting for roughly 10-20% of the phospholipid carboxylic acid content typically.
Arachidonic acid may be a key inflammatory intermediate and may also act as a vasodilator.
 Two major classes of enzymes, cyclooxygenases (COX) and lipoxygenases (LOX), are recognized for his or her prominent role in generating variety of important biological mediators. Among these, prostaglandins (PGs) and leukotrienes (LTs) are widely studied given their recognized role in human disease conditions also as physiological and/or pathophysiological activities. of those biological actions, one among the foremost significant is that the major role played by eicosanoids in inflammation, where they contribute to all or any of the clinical symptoms related to the inflammatory condition, namely, pain, redness, and swelling. 

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