Current Trends in Cardiology

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Current Trends in Cardiology 44 7897 074717

Aortic Stenosis Review Articles

Aortic stenosis (AS) may be a common valvular heart condition within the Western populations, with an estimated overall prevalence of three in adults over 75 years. to know its pathos-biological processes represents a priority. In elderly patients, AS usually involves trileaflet valves and is mentioned as degenerative calcific processes. Scientific evidence suggests the involvement of a lively “atherosclerosis-like” pathogenesis within the initiation phase of degenerative AS. To the contrary, the progression might be driven by different forces (such as mechanical stress, genetic factors and interaction between inflammation and calcification). The improved understanding presents potentially new therapeutic targets for preventing and inhibiting the event and progression of the disease. Furthermore, in clinical practice the management of AS patients implies the evaluation of generalized atherosclerotic manifestations (i.e., within the coronary and carotid arteries) even for prognostic reasons. In counselling elderly patients, the danger stratification should address individual frailty beyond the generic risk scores.

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