Evaluation of the hypolipidemic and antioxidant potential of cashew apple powder: A study with high cholesterol diet induced hyperlipidemic Wistar rats
17th International Conference on Clinical Nutrition and Fitness
November 21-22, 2019 | Singapore
IIT Bombay, India
Posters & Accepted Abstracts : J Nutr Hum Health
Claim: This first-ever animal study reports safety and
therapeutic impact of cashew apple powder as a functional
food, effective in the management of secondary complications
associated with high-cholesterol diet (HCD). The results indicate
that cashew apple powder is effective in lowering cholesterol
level, and potentially, antioxidant in rats fed with HCD.
Design: An 8-week-long (4 week High cholesterol diet, next 4 week treatment phase) safety and efficacy study investigated the hypolipidemic and antioxidant potential of cashew apple powder (low dose: 400 mg/kg BW and medium-dose: 800 mg/kg BW) in Wistar rats fed with a high-cholesterol diet. The study involved seven groups (controls: NC1, NC2; disease: DC; Tests: TEST1, TEST2; and standards: STD 1, STD 2) of 8 rats (four males and four females) each.
Results: The total cholesterol level significantly (p < 0.001) lowered in all the groups in comparison with DC. The total cholesterol level started decreasing prominently from day 14 (2nd week of treatment) in females, and from day 28 (4th week of treatment) in males. Regarding oxidative stress as evaluated from liver tissue, the levels of catalase, GSH, and SOD decreased significantly (p < 0.001) in DC in comparison with NC. The levels of these markers increased significantly (p < 0.001) in STD and TEST in comparison with DC. Similarly, the MDA level decreased significantly (p < 0.001) in STD and TEST in comparison with DC.