Cardiac Excitation – Contraction Coupling
Joint Event on 3rd World Congress on Cardiology & 16th International Conference on Nutrition and Fitness
October 29-30, 2018 | London, UK
University of Bristol, UK
Posters & Accepted Abstracts : J Nutr Hum Health
Calcium signalling is pivotal for cardiac function, but the complex interaction between cell structure, protein expression and function is far from clear. While the discovery of calcium sparks now forms a cornerstone for our understanding of cardiac excitation-contraction coupling, the problem of calcium spark termination has been resistant to clarification. Using detailed computer models, we now have a robust explanation of calcium spark termination that depends on the detailed microanatomy of the cardiac cell. Furthermore, we have found that disrupted cell anatomy, in the form of de-tabulation, is very closely linked to the loss of contractile performance seen in heart failure. Loss of t-tubules will reduce the efficiency of excitation-contraction coupling but also promote“late calcium sparks” which prolong the calcium transient and would be pro-arrhythmic. These late calcium signalling events are likely to become a new area for intensive study as we attempt to link deranged calcium signalling to arrhythmias and sudden cardiac death.