Archives of Industrial Biotechnology

A novel plasma membrane regulator of Calcium homeostasis in yeasts

World Yeast Congress
May 14-15, 2018 | Montreal, Canada

Linghuo Jiang

Shandong University of Technology School of Agricultural Engineering and Food Science, China

Posters & Accepted Abstracts : Arch Ind Biotechnol

Abstract:

Homologous to the vertebrate solute carrier SLC10A7, Rch1 is a novel regulator of calcium homeostasis in the plasma membrane of the budding yeast Saccharomyces cerevisiae and the human yeast pathogen Candida albicans. ScRCH1 is a functional homolog of CaRCH1. ScRch1 and CaRch1 negatively regulate the calcium uptake in response to high levels of extracellular calcium in S. cerevisiae and C. albicans, respectively. However, CaRch1 is constitutively expressed, while ScRch1 is induced by a high level of calcium ions. Transcriptional expression of ScRCH1 is positively regulated by calcium/calcineurin signaling through the sole CDRE element in its promoter. Furthermore, distribution of ScRch1 proteins in the plasma membrane changes in a dynamic way, from multiple foci prior to cell division, accumulation at the bud neck during bud growth, and dispersion along the plasma membrane immediately prior to cytokinesis. Rch1 is a novel member regulating calcium homeostasis in yeasts. e: linghuojiang@hotmail.com

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