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Journal of Timely Topics in Clinical Immunology | Volume 2
July 26-28, 2018 | Moscow, Russia
Immunology
11
th
Annual Congress on
Molecular Biology of Oral Cancer and Role of Cyclin D1 in Oral Premalignant Lesions and Oral Squamous
Cell Carcinoma – A review of original Study
Rohit B.Moharil
VSPM Dental College & Research Centre, India
C
arcinogenesis is a complex, multi-step process in which
geneticeventswithinsignaltransductionpathwaysgoverning
normal cellular physiology are quantitatively or qualitatively
altered (Vogelstein and Kinzler, 1993). The genetic basis of
cancer is nowwell-established. Under normal conditions, these
tightly controlled excitatory and inhibitory pathways regulate
oral keratinocyte biology. Aberrant expression of the proto-
oncogene epidermal growth factor receptor (EGFR)/c-erb1,
members of the ras family, as well as cmyc, int-2, HST, Cyclin- D1,
and bcl-1, is believed to contribute to oral cancer development.
Cyclin D1 is a protein derived from PRAD1 or CCND1 or Bcl-
1gene located on chromosome 11q13 and it acts as a positive
regulator of the cell cycle in normal cells as well as in neoplasia.
Over expression of cyclin D1 may lead to shortening of G1
phase, increased cell proliferation and reduced dependency
on growth factors. Our immunohistochemical study results
showed that the alteration of cyclin D1 is frequent in oral
precancer and oral squamous cell carcinoma. Expression of
cyclin D1 was significantly altered from oral epithelial dysplasia
to oral squamous cell carcinoma indicating that over expression
of cyclin D1 may be an early event in oral cancer development.
e:
drrohitmoharil@gmail.com