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Journal of Timely Topics in Clinical Immunology | Volume 2
July 26-28, 2018 | Moscow, Russia
Immunology
11
th
Annual Congress on
The World Incidence and Prevalence of Autoimmune Diseases is Increasing
Aaron Lerner
AESKU.KIPP Institute, Germany
E
pidemiological data provide evidence of a steady rise in
autoimmune disease throughout Westernized societies
over the last decades. Multiple publications exist, describing
past or actual incidences/prevalence of individual autoimmune
diseases, however, long term studies on selected populations
are scarce. Aims: to calculate the % increases per year of
autoimmune diseases frequencies worldwide, analyse the
differential increases per country and disease, and identify
epidemiological trends. Results: The means ± s.d. of the net
% increased/year incidence and prevalence of autoimmune
diseases worldwide were 19.1±43.1 and 12.5±7.9, respectively.
Rheumatic, endocrinological, gastrointestinal and neurological
autoimmune diseases revealed the following annual %
increases per year: 7.1, 6.3, 6.2, and 3.7, respectively. In
all of these, differences between old vs new frequencies
were highly significant (p<0.0001). Comparing various
autoimmune diseases, celiac disease increased the most
and the highest increase in incidence, comparing old to new
surveys is allocated to myasthenia gravis. Despite considerable
variations between the countries, celiac, type 1 diabetes
and myasthenia gravis frequencies increased the most in
Canada, Israel and Denmark, respectively. Frequencies of
the autoimmune diseases increased significantly in the West
and North when compared to East and South, respectively.
Conclusions: Despite multiple reports on autoimmune diseases
frequencies, long-term longitudinal follow-ups are scarce.
Incidences and prevalence’s have increased significantly
over the last 30 years. Rheumatic, endocrinological and
gastrointestinal autoimmune diseases in Israel, Netherlands,
USA and Sweden increased the most. These observations point
to a stronger influence of environmental factors as opposed
to genetic factors on autoimmune disease development.
e:
aaronlerner1948@gmail.com