immunology-congress-2018-posters-abstracts

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Journal of Timely Topics in Clinical Immunology | Volume 2

July 26-28, 2018 | Moscow, Russia

Immunology

Annual Congress on

Proteolytic enzymes in the pathogenesis of the influenza virus

Valentina Divocha

Lugansk State Medical University, Ukraine

eproteinization of a flu virus is necessary for its penetration

into a cell and this occurs for the account of trypsin-like

proteinases of the host’s cell. We assumed that this enzyme has

an important role inmorphogenesis of fluvirus and considerably

defines its pathogenic and virulent properties.

Objective:

to study the changes of proteinase and inhibitor

activities in the development of influenzal infection at white

mice previously infected with flu A virus.

Results:

It has been being established that the level of trypsin-

like proteinase and its inhibitor in the lungs and blood serum

of not infected white mice were in balance at rather high level

and did not change considerably during the whole period of

supervision (6 days). At infection of white mice with virus of

flu A/PR/8/34 (H1N1) there was a violation of proteinase-

inhibitory balance. The most profound changes happened

during the first hours after infection. There was the growth of

proteinase activity and decrease of inhibitory activity. During

the maximum accumulation of infectious titer of virus and its

hemagglutinin, both proteinase and inhibitory activity was

completely suppressed. The animals which didn’t perish for 5-6

days increase of inhibitory activity and decrease in proteinase

took place.

Conclusions:

Increase of proteinase activity during the

first hours after infection led to increase of infectious and

hemagglutinating activity. The increase of inhibitory activity

in 5-6 days after infection leads to some arresting of influenzal

infection.