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Journal of Timely Topics in Clinical Immunology | Volume 2
July 26-28, 2018 | Moscow, Russia
Immunology
11
th
Annual Congress on
New autoantibodies in spondyloarthritis
Guixiu Shi
Hospital of Xiamen University, China
S
pondyloarthritis (SpA) is a common inflammatory disorder.
because the lack of specific laboratory biomarker. The
diagnosis of SpA is relying on clinical examination and x-ray
of the spine which show characteristic spinal changes and
sacroiliitis. However, abnormalities in x-ray often occur several
years after the onset of the disease. Autoantibodies are widely
used as biomarkers in many types of autoimmune diseases and
other diseases. We used proteomic approach to screen new
autoantigens inSpApatients.Wedetectedonenewautoantigen
in SpA sera named as SPA1. Using ELISA technology, IgG
autoantibody to SPA1was found in 24.4%of the SpA patients. In
the controls, the prevalence of the new autoantibody was 6.8%
in health controls, 16.7% in systemic lupus erythematosus, 0%
in psoriatic arthritis and gout. The titer of anti-SPA1 was close
associated with disease activity of SpA. Antibody against SPA1
could provide an important additional tool for diagnosis of SpA.
e:
gshi@xmu.edu.cn