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Journal of Timely Topics in Clinical Immunology | Volume 2

July 26-28, 2018 | Moscow, Russia

Immunology

Annual Congress on

Differential modulation of immune functions by food borne mycotoxins

Mohammad Rafiqul Islam

Bangladesh Society for Molecular Immunology and Advanced Biotechnology, Bangladesh

ycotoxins are structurally diverse toxic secondary

metabolites produced by the organisms of the Fungus

kingdom. Citrinin (CTN) was first isolated as a secondary

metabolite of Penicillium citrinum and can cause mycotoxic

nephropathy, cytotoxicity and genotoxicity. Deoxynivalenol

(DON) is a secondary metabolite produced by Fusarium fungi

and a contaminate in wheat, barley and corn worldwide. DON

has been implicated in inducing dysregulation of the immune

response and is able to either enhance or suppress resistance

to pathogens. Zearalenone (ZEN) is a non-steroidal estrogenic

mycotoxin produced by various Fusarium species. ZEN is mainly

known as a hormonal disrupter due to its estrogenic activities

and consequent toxicity for reproduction. ZEN also displays

hepatotoxicity, immunotoxicity and nephrotoxicity. Due to the

widespread presence of fungi in the environment, CTN, DON

and ZEN are regarded as an unavoidable contaminant in food

products. However, the immunomodulatory effects of CTN,

DON and ZEN in mice have not been yet fully elucidated. In the

present study, we have investigated the immune modulatory

effects of CTN, DON and ZEN in the female BALB/c mice.