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Journal of Timely Topics in Clinical Immunology | Volume 2

July 26-28, 2018 | Moscow, Russia

Immunology

Annual Congress on

The key to manufacturing viral vaccines for individual human population

Tirasak Pasharawipas

Rangsit University, Thailand

owadays, subunit viral vaccine becomes the major choice

for manufacturing viral vaccine with a thought of safety

reason to prevent side effects. However, the success to use

subunit viral vaccine to prevent a particular viral infection is

very limit. This is different from the time when Cowpox virus

was originally used for vaccination to prevent the smallpox

viral epidemic over a century ago. Although the knowledge

of immunity has been discovered a lot more than the Edward

Jenner’s period, the effectiveness of viral vaccine could not

reach our accomplishment. Accordingly, we need to revise our

knowledge and manipulate in the right direction for the viral

vaccineproduction. Basically, to inducean immunity toprevent a

viral infection, our bodymust produce a specific antibody which

needs inductionnot onlyby aparticular viral antigenbut also the

molecules calledmajor histocompatibility complex (MHC). Each

moleculeofMHCalleles plays a key role in the immune response

by forming a specific complex with its appropriate epitope to

induce a specific T cell clone thru its specific receptor. MHC class

I is required for inducing cytotoxic T cell while MHC class II is for

helper T cell. Helper T cell plays a key role to induce an effective

stage of acquired immunity especially a specific antibody which

is believed to be a gearwheel to prevent an invasion of the

particular viral particle. To produce the viral-specific antibody,

MHC class II plays a key role to induce helper T cell and then B

cell to synthesize a specific antibody. Since theMHC gene alleles

are highly polymorphic so the possibility that individuals have

the same gene alleles might be one in a million which, mostly,

can be found in those who are an identical twin. Accordingly,

a subunit viral vaccine, which contains a limit number of

epitopes, would reduce a capacity of an antigen presenting cell,

such as a dendritic cell, to process some epitopes to induce the

particular helper T cell clones. Subsequently, the corresponding

B cell clones cannot synthesize the specific antibody to

neutralize the particular infectious viral particle. Accordingly,

this presentation will present a different notion and principle

to develop a viral vaccine for an individual human population.