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J u l y 2 3 - 2 4 , 2 0 1 8 | R o m e , I t a l y
allied
academies
Joint Event on
Cardiology Congress 2018 & Microbe Infection 2018
Biomedical Research
|
ISSN: 0976-1683
|
Volume 29
2
nd
World Congress on
CARDIOLOGY
MICROBIOLOGY AND MICROBIAL INFECTION
&
39
th
Annual Congress on
Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C1-003
THE CHALLENGES IN MANAGING HEART FAILURE WITH PRESERVED
EJECTION FRACTION (HFPEF)
Samer Ellahham
Cleveland Clinic, USA
T
he learning objectives of the current study is to demonstrate the association between heart failure with preserved ejection
fraction (HFpEF) and survival, given a patient with heart failure (HF), recognize HFpEF based on clinical signs and symptoms,
physical examination, echocardiography, and radiographic findings, classify patients at high risk of hospitalization and mortality
through assessing risk factors, clinical presentation, and interpretation of biomarkers, distinguish the clinical presentation,
diagnosis, and treatment strategies of HFpEF from those of HF with reduced ejection fraction, given a patient with HFpEF,
develop an individualized treatment plan based on current evidence and assess the potential role of future pharmacotherapies
for HFpEF. Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF) and, as life expectancies
continue to increase in western societies, the prevalence of HFpEF will continue to grow. In contrast to heart failure with reduced
ejection fraction (HFrEF), no treatment has been proven in pivotal clinical trials to be effective for HFpEF, largely because of the
pathophysiological heterogeneity that exists within the broad spectrum of HFpEF. This syndrome was historically considered
to be caused exclusively by left ventricular diastolic dysfunction, but research has identified several other contributory factors,
including limitations in left ventricular systolic reserve, systemic and pulmonary vascular function, nitric oxide bioavailability,
chronotropic reserve, right heart function, autonomic tone, left atrial function and peripheral impairments. Multiple individual
mechanisms frequently coexist within the same patient to cause symptomatic heart failure, but between patients with HFpEF the
extent to which each component is operative can differ widely, confounding treatment approaches. This lecture focuses on our
current understanding of the pathophysiological mechanisms underlying HFpEF, and how they might be mechanistically related
to typical risk factors for HFpEF, including ageing, obesity and hypertension.
samerellahham@yahoo.com