cardiology-congress-microbe-infection-2018-posters

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J u l y 2 3 - 2 4 , 2 0 1 8 | R o m e , I t a l y

Note:

allied

academies

Joint Event on

Cardiology Congress 2018 & Microbe Infection 2018

Biomedical Research

ISSN: 0976-1683

Volume 29

World Congress on

CARDIOLOGY

MICROBIOLOGY AND MICROBIAL INFECTION

Annual Congress on

Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C1-003

ELECTRON MICROSCOPIC STUDIES OF BRAIN TISSUE IN FETUSES FROM

SCHIZOPHRENIC MOTHERS

Segundo Mesa Castillo

Havana Psychiatric Hospital, Cuba

he neurodevelopmental theory in the aetiology of schizophrenia is considered one of the most consistent at present.

Evidence from epidemiological and neuropathological studies indicates that the pathogenic process that culminate in the

development of schizophrenia are initiated early in life and has been associated with a variety of prenatal environmental insults

to the developing brain, including infection. Although the infectious agents have been proposed as one of the risk factors for

schizophrenia the data on the association of a specific infectious agent with prenatal brain evidence is absent. Understanding

of the structural abnormalities would allow a better identification of neurodevelopmental processes that contribute to risk for

schizophrenia. We have hypothesized that at ultra high-risk fetuses would have alterations at cellular level that would let us

differentiate them to the comparison subjects. A reappraisal of our ultrastructural studies carried out in samples of the left

temporal lobe of fetuses at ultra-high risk of developing schizophrenia is presented. The findings obtained are compatible with

an active infection of the central nervous system by herpes simplex hominis type I [HSV1] virus. The present results are the first

direct evidence that demonstrate the presence of this virus in the central nervous system of fetuses from schizophrenic mothers

in the critical period of fetal development. The importance of this finding can have practical applications in the prevention of the

illness keeping in mind its direct relation to the aetiology and physiopathology of schizophrenia.