Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-7360-538437

Research Article - Biomedical Research (2017) Volume 28, Issue 21

Risk factors for adverse fetal outcomes in patients with intrahepatic cholestasis of pregnancy

Objective: To evaluate relevant risk factors for adverse fetal outcomes among patients with Intrahepatic Cholestasis of Pregnancy (ICP).

Methods: We performed a retrospective analysis, data were obtained for all women with ICP admitted to hospital between January 2014 to December 2015. Patients were divided into group A (no adverse fetal outcomes) and group B (adverse fetal outcomes). They were further divided into mild ICP and severe ICP on the basis of severity. The frequency of adverse fetal outcomes was assessed.

Results: Among 313 eligible women, 223 (71.2%) were mild ICP and 90 (28.8%) were severe ICP. By multivariate regression logistic analysis, Total Bile Acid (TBA) and twin pregnancy were the risk factors for adverse fetal outcomes among patients (p=0.001 and p<0.001, respectively). Receiver operating characteristic curve analysis revealed that the level TBA could be used as a predictor of adverse fetal outcomes with a 59.7% sensitivity and a 56.3% specificity when the cut-off value was 24.1 μmol/L at the time of diagnosis of ICP.

Conclusion: Patients with severe ICP, twin pregnancy and high TBA level should be considered more intensive surveillance for possible adverse fetal outcomes.

Author(s): Li Li, Lin Cong, Yuanhua Chen, Yuanyuan Yang

Abstract Full Text PDF

Get the App