Journal of Clinical Ophthalmology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-7360-538437

Research Article - Journal of Clinical Ophthalmology (2023) Volume 7, Issue 1

An eye-tracking-based binocular amblyopia treatment improving both visual acuity and binocularity: One year follow-up.

Background: Amblyopia is a neurodevelopmental disorder resulting from abnormal visual experience early in life.

Purpose: To evaluate the efficacy and safety of a novel binocular eye-tracking-based passive home treatment system delivering personalized amblyopia therapy.

Methods: Real-time foveal area blur was induced on the dominant eye of 20 participants (aged 4-15 years) with anisometropic, strabismic (<5 PD), or mixed amblyopia in a prospective single- arm proof-of-concept human study. Subjects were trained over 12 weeks with 5 weekly sessions and then for an additional 12 weeks with 3 weekly sessions. Primary outcome was improvement in Best Corrected Visual Acuity (BCVA) and stereoacuity. Secondary outcomes were adherence, improvement persistence and patient-reported comfort.

Results: Mean BCVA significantly improved by 0.19 ± 0.11 logMAR for distance crowded VA, 0.27 ± 0.13 logMAR for near crowded VA, and by 0.22 ± 0.15 logMAR for distance single letter VA (p<0.001 for each). Stereoacuity improved by 198 ± 218 arcsec (p=0.001). Binocular VA improved 0.09 ± 0.13 logMAR for distance crowded VA (p=0.007), 0.12 ± 0.11 logMAR for near crowded VA (p<0.001) and 0.07 ± 0.12 logMAR for distance single letter VA (p=0.018). The adherence rate was 89% ± 27%. No patient reported discomfort. At 52 weeks, distance crowded VA, distance single letter VA, and stereoacuity were not significantly different from the end-of- treatment measurements.

Conclusion: The system improved VA and stereoacuity and produced a high adherence rate with no reported discomfort. Improvement persisted for 6+ months.

Translational relevance: A novel binocular treatment based on passive viewing of customized content, modified to reinforce the amblyopic eye, resulted in VA and stereoacuity improvement in a small, first-in-human study, suggesting that this treatment might reduce interocular suppression.

Author(s): Tamara Wygnanski-Jafe, Michael Belkin, Oren Yehezkel

Abstract Full Text PDF

Get the App