Research Article - Journal of Clinical Ophthalmology (2019) Volume 3, Issue 1
Comparison of difluprednate 0.05% versus prednisolone acetate 1% eye
drops following uneventful cataract surgery.
Purpose: To compare intraocular pressure (IOP) readings and postoperative inflammation between 2
corticosteroid drops: difluprednate (DP) ophthalmic emulsion 0.05% and prednisolone acetate (PA)
1.0% after uneventful cataract surgery.
Patients and methods: randomized, controlled study of 343 patients undergoing uneventful cataract
surgery in one eye. Randomization was used to allocate patients to either group: receive prednisolone
acetate 1% five times daily or difluprednate 0.05% four times daily for 14 days post-surgery, then
tapered over 14 days. Intraocular pressure was measured preoperative, 1st day, 1st week, and one
month postoperative. Also, ocular inflammation was monitored in the form of anterior chamber (AC)
flare, AC cells, corneal edema and conjunctival congestion.
Results: No statistically significant difference in IOP between both groups was detected on
postoperative first day and after one month. Yet there was statistically significant difference after first
and second week of treatment with higher levels in the difluprednate group. As for ocular
inflammation all signs resolved by the end of a month postoperative with no significant difference
between both groups.
Conclusion: There was significant increased intraocular pressure in the difluprednate group than in
the prednisolone acetate group which might be attributed to the increased dosing and duration of use
of difluprednate. Author(s): Islam Saad El Saman, Engy Mohamed Mostafa, Ahmed Gad Kamel, Osama Ali Mohammed
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