Case Reports in Surgery and Invasive Procedures

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Case Reports in Surgery and Invasive Procedures 44 7897 074717

Toxicokinetics Innovations

Genetic Toxicology plays a major role in protection of personnel and surrounding community. They address the health events in acute events. The comparison of toxicology exposure parameters to therapeutically effective exposure parameters gives rise to the idea of a therapeutic window, or the space between efficacy and toxicity. This is depicted in a theoretical example below. Innovations are new idea, device or process.

The epithelial barriers that form the body’s interface with the environment, and the cellular barriers that separate internal organs and tissues, have to be permeable to a wide variety of chemicals to allow nutrient absorption and waste product elimination. The permeability of these physiological barriers, however, also allows toxicants to penetrate.  The degree of adverse effects following exposure to a toxicant is dependent on the rate and extent of absorption into the body, distribution to susceptible organs and tissues, and specific interactions with biological targets.

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