Timely Topics in Clinical Immunology

Timely Topics in Clinical Immunology 44 7897 074717

Mutations In HIV Patients Peer-review Journals

 

A permanent change in the genetic material of a cell or microorganism. Some mutations can be transmitted when the cell or microorganism replicates. Some HIV mutations cause the virus to become resistant to certain antiretroviral (ARV) drugs.

Acquired HIV drug resistance can happen when a person has HIV that is replicating (making copies of itself), but is also taking a particular antiretroviral medication. HIV can mutate “around” that medication. This will result in HIV being resistant to the medications and those medications now being ineffective.

Antiretroviral treatment (ART) has improved the global health in HIV-infected patients, reducing the mortality rates especially in resource-poor countries. In Latin America and the Caribbean there are different factors that have been related to the development of drug resistance such as long-term ART administration, low access to second-line therapy and limited genotyping test. Fortunately, standardized genotyping test is available from most of these countries that have been used to monitor the resistance primary.

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