Journal of Cell Biology and Metabolism

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Journal of Cell Biology and Metabolism 44 7897 074717

MOLECULAR SIGNATURES JOURNALS

Tumor recurrence and metastases are the main obstacles to enhance the prognosis of patients with hepatoma (HCC).the identification of blood-based diagnostic and prognostic biomarkers that surpass existing clinicopathologic factors in gauging the danger of early recurrent disease in patients with HCC and therefore the development of HCC in high-risk CHB patients.To identify novel molecular signatures related to HCC recurrence and metastases, we've established an expression database of HCC patients using Affymetrix gene chips. Samples from patients with early recurrent disease were compared with non-recurrent human HCC tissue samples (recurrence is defined as recurrent disease occurring within a 2-year time point of the first treatment). Novel biomarkers related to early HCC recurrence are characterized and are being employed as diagnostic markers for early recurrent disease.Metastasis that's liable for the bulk of cancer-related deaths is initiated by cancer cells that are shed and disseminated through the circulation from the first tumor to distant organs (circulating tumor cells, CTCs). Although the detection of CTCs may have important prognostic and therapeutic implications, their detection poses key technical challenges because their numbers are often very small. Great efforts have therefore been made toward the enhancement of signal amplification to significantly increase the sensitivity for the detection of tumor-specific biomarkers on the surface of CTCs.High sensitivity is achieved by using graphene to switch the immunosensor surface to accelerate electron transfer and quantum dot (QD)-coated silica nanoparticles as tracing tags. On the opposite hand, high specificity is obtained by the simultaneous measurement of multiple HCC-specific biomarkers, identified through the microarray studies, on the cell surface of CTCs using different QD-coated silica nanoparticle tracers.(Kam Man Hui, Identification of blood-based molecular signatures to detect early human hepatocellular carcinoma).

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