Journal of Clinical Endocrionology Research

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Journal of Clinical Endocrionology Research 44 7897 074717

Metabolic Homeostasis:

Metabolic homeostasis is ensured by complex interactions between the Central Nervous System (CNS) and peripheral tissues. The CNS controls the periphery by regulating the fraction of energy which enters the organism (food intake) and that which leaves the organism (thermogenesis). Central regulation of energy metabolism. In normal individuals, food intake and energy expenditure are tightly regulated by homeostatic mechanisms to maintain energy balance. Substantial evidence indicates that the brain, particularly the hypothalamus, is primarily responsible for the regulation of energy homeostasis. Metabolic homeostasis is ensured by complex interactions between the Central Nervous System (CNS) and peripheral tissues. The CNS controls the periphery by regulating the fraction of energy which enters the organism (food intake) and that which leaves the organism (thermogenesis). To be able to exert this role, the CNS receives signals from peripheral organs that convey information on the extent of body energy stores. When this information is integrated, the CNS responds via efferent regulatory signals channeled mostly via the endocrine and the autonomic nervous system. Amongst the several feedback signals arising from peripheral tissues, leptin and ghrelin are important ones. Leptin is a hormone that is synthesized in adipose tissue.

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