Allied Journal of Medical Research

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Allied Journal of Medical Research 44 7897 074717

Importance Of Glycomics

In comparison with genomics and proteomics, the advancement of glycomics has faced unique challenges within the pursuit of developing analytical and biochemical tools and biological readouts to research glycan structure-function relationships. Glycans are more diverse in terms of chemical structure and knowledge density than are DNA and proteins. This diversity arises from glycans' complex nontemplate-based biosynthesis, which involves several enzymes and isoforms of those enzymes. Consequently, glycans are expressed as an 'ensemble' of structures that mediate function. Moreover, unlike protein-protein interactions, which may be generally viewed as 'digital' in regulating function, glycan-protein interactions hit biological functions during a more 'analog' fashion which will successively 'fine-tune' a biological response. This fine-tuning by glycans is achieved through the graded affinity, avidity and multivalency of their interactions. Given the importance of glycomics, this review focuses on areas of technologies and therefore the importance of developing a bioinformatics platform to integrate the various datasets generated using the various technologies to permit a systems approach to glycan structure-function relationships.

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