Hematology and Blood Disorders

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Hematology and Blood Disorders 44 7897 074717

Hyperammonemia Neonatal Disease Scholarly Peer Review Journal

Hyperammonemia is a biochemical disorder characterized by elevated ammonia levels in the blood. Increased influx of ammonia into the brain is a primary cause of neurological disorders such as congenital urea cycle enzyme defects, hepatic encephalopathies, Reye syndrome, some other metabolic disorders and several toxic encephalopathies. Hyperammonemia is a life-threatening condition which should be promptly approached for intervention. In addition, hyperammonemia is caused by respiratory alkalosis arising from a ventilation stimulus. In a patient with unexplained vomiting, lethargy or some form of encephalopathy, plasma ammonia levels should always be examined. Presentation of hyperammonemia in neonates with UCDs is usually that of an unremarkable newborn term-gestation that is perfect for the first couple of days of life. Progressive protein consumption, however, results in nitrogen deficiency and hyperammonaemia, typically during the first week of life.

 

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