Biomedical Research

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Biomedical Research 44 7897 074717

Cytotoxicity Journals Impact Factor

The term is often used to describe chemotherapy drugs that kill cancer cells, but it may also be used to describe toxins, such as venom. Within our own immune systems, we have cells that are considered cytotoxic, such as the T cells that kill bacteria, viruses, and cancer cells. The label "cytotoxic" is important for medical professionals who will be handling cytotoxic medications or other substances that can cause cell death, and specific precautions are necessary for safety. Cytotoxicity testing is important in ensuring safety ranging from environmental exposures to medical devices. The cells are allowed to grow in the extract fluid for a specified amount of time before the cells are evaluated using either qualitative or quantitative methods. The test is performed on all medical devices with patient contact, raw materials, and devices undergoing a cleaning validation or residual manufacturing.

most of the time the term "cytotoxic" refers to the effect that a chemotherapy drug has on cancer cells. In this sense, a cytotoxic agent may be differentiated from one that is cytostatic. A cytostatic medication would, in contrast, inhibit cell division and growth but would not result in cell death directly. Cytotoxic compounds mainly cause carcinogenic, mutagenic and teratogenic effects on exposure. The cytotoxic compounds affects the cells by causing uncontrolled cell death, prevents cell growth and cell division. The ability of cytotoxic compounds to prevent the cell division can be utilized to prevent the uncontrolled proliferation of cancer cells.

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