Allied Journal of Medical Research

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Allied Journal of Medical Research 44 7897 074717

Chemical Risk Assessment

Chemical risk assessment was codified for federal agencies in 1983 by the National Research Council (NRC) of the National Academy of Sciences. A number of other NRC reports have since provided guidance on ways to assess risks of chemicals, including reports that highlighted the disparity between the rate of deployment of new anthropogenic chemicals and assessment of their potential risks to public health. Central to these evolving recommendations has been to replace the current practice of extensive animal-based characterization of chemical hazard, dose–response relationships, and extrapolation to human health with high-throughput in vitro tests, in silico models, and evaluations of efficacy at the human population level. In addition, . In addition human and biological system hazard evaluations require dependable methodologies for presentation to these synthetic substances.

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