Journal of Diabetology

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Journal of Diabetology 44 7897 074717

Articles On Polygenic Disorder

Polygenic diseases are due to the joint contribution of a number of individually acting or cooperating polymorphic genes; the separate contribution of each gene could be small or even unnoticeable. The carriage of specific combinations of genes can identify the incident of clinically heterogeneous forms of the disease and treatment efficacy. This review describes the approaches used in a polygenic analysis of data in medical genomics, in particular, pharmacogenomics, aimed at identifying the cumulative effect of genes. This impact may result from the addition of gains of various genes or be caused by the epistatic interaction between the genes. Both cases are undoubtedly of great interest in investigating the nature of polygenic diseases.

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