Hematology and Blood Disorders

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Articles On Coagulation Disorders

Blood coagulation, in medicine. The mechanism by which the blood clots to form dense masses, or clots. More than 30 cell types and blood substances impair coagulation. The cycle is started with platelets in the blood. Platelets contain a product that combines to form thromboplastin with calcium ions in the blood, which in effect converts the protein prothrombin into thrombin in a complex sequence of reactions.Thrombin, a proteolytic enzyme, transforms fibrinogen, a protein substance, into fibrin, an insoluble protein that forms an intricate network of minute thread-like structures called fibrils, causing gel to the blood plasma. To form the clot, the blood cells and plasma are enmeshed into the fibril network.In medicine, the mechanism of the creation of a blood clot.

 

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