Journal of Cell Biology and Metabolism

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Journal of Cell Biology and Metabolism 44 7897 074717

Abnormal-RBCs

Red blood cells (RBCs) play a main role in microcirculation and oxygen delivery to organ and tissues. This role is decided by their ability to deform and to undergo the vessels that are even smaller than RBC size. there's in depth relationship between RBC deformability and its unique disc shape. Under different circumstances, RBC may change their shape and undergo echinocyte, stomatocyte or spherocyte transformation. Echinocytes or stomatocytes are potentially capable to revive the disc shape if they're put in favorable environment (e.g. fresh normal plasma), whereas the spherocyte transformation is taken into account to be irreversible. In-vitro studies using micropore filtration technique demonstrated that standard RBCs (discocytes) have an optimum shape for the flow in microvessels. In contrast to discocytes, stomatocytes and echinocytes produced by adding chlorpromazine or analgesic, respectively, to normal RBCs demonstrated altered passage through circulation. Mechanisms of microcirculatory disorders in critical conditions like trauma-hemorhagic shock, sepsis or burn are under investigation for many years. Mechanisms of microcirculatory disorders in critical conditions like trauma-hemorhagic shock, sepsis or burn are under investigation for many years.

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