THE PREVENTIVE EFFECT OF DATE PALM (PHOENIX DACTYLIFERA) SEED AND FRUIT HYDROALCOHOLIC EXTRACTS ON CARRAGEENAN-INDUCED INFLAMMATION IN MALE RATS HIND PAW
Joint Event on International Congress on DERMATOLOGY AND TRICHOLOGY & 2nd WORLD NEPHROLOGY AND THERAPEUTICS CONGRESS
September 20 - 21, 2018 | Rome , Italy
Ahvaz University Medical Science, Iran
Posters & Accepted Abstracts : Arch Gen Intern Med
Background & Objective: The side effects of NSAIDS drugs, have caused increasing interest of scientists in herbal medicines as alternative treatment. In this study, the effect of anti-inflammatory of seed and fruit of date palm hydroalcoholic extracts, due to having antioxidants, was studied. Materials & Methods: In this study, the extracts of date palm seed and fruit were prepared by maceration method in 70% alcohol. 80 male rats Wistar, divided into 10 groups of eight in each, four groups received different doses (100, 200, 400 and 600 mg/kg) of seed extract and four other groups different doses (100, 200, 400 and 600 mg/kg) of fruits extract of the palm, and the positive control aspirin (300mg/kg) and the negative control group saline (5ml/kg) via injection intraperitoneally. Half an hour later all animals received 100 Î¼l of 1% carrageenan into the ratsâ hind paw subcutaneous. The changes in rats paw edema was measured by plethysmometer every hour for five hours. Results: The effect of all the doses of date palm seed extract on edema were less than aspirin (P<0.05). But there was no significant difference between the group that received 400 and 600 mg/kg date palm fruit extract when compared with aspirin group. The dose 400 mg/kg of fruit extract showed the most anti-inflammatory effect and it was assigned as the best dose. Conclusion: It is likely that with further studies on different model of animals and on human model the palm fruit extract could be used for pain treatment.