Microbiology: Current Research

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Mycobacterial lineages causing pulmonary and extra pulmonary tuberculosis, Ethiopia

Joint Event on International Conference on Emerging Diseases, Outbreaks & Case Studies & 16th Annual Meeting on Influenza
March 28-29, 2018 | Orlando, USA

Teklu Kiros Woldegebriel

Yang-Ming University, Taiwan

Posters & Accepted Abstracts : Microbiol Curr Res


Molecular typing of 964 specimens from patients in Ethiopia with lymph node or pulmonary tuberculosis showed a similar distribution of Mycobacterium tuberculosis strains between the two disease manifestations and a minimal role for M. bovis. We report a novel phylogenetic lineage of M. tuberculosis strongly associated with the Horn of Africa. Ethiopia is among the countries with the highest incidence of tuberculosis (TB) and has a yearly incidence of 261 cases/100,000 population. TB lymphadenitis in cervical lymph nodes (TBLN) accounts for ≈33% of all new cases in this country, which is greater than the global average of ≈15%. Ethiopia has the largest livestock population in Africa (≈51 million cattle), and recent studies have shown that bovine TB is endemic in this country (estimated prevalence 1%–10%). To explore the public health risk for bovine TB in Ethiopia, we have used molecular typing to characterize mycobacterial isolates from persons with TBLN and pulmonary TB who were visiting hospitals throughout the country. Our aim was to define the role of Mycobacterium bovis in human TB and to define the overall structure of the M. tuberculosis complex in Ethiopia. e: kmengie@yahoo.com


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