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Influenza vaccination of patients with autoimmune rheumatic disease
4th International Conference on Medical Microbiology
May 20-21, 2019 | Vienna, Austria
Stojanovich L
University Medical Center Bezanijska kosa, Serbia
Posters & Accepted Abstracts : Microbiol Curr Res
Abstract:
Objectives: Compared to the healthy population, patients
suffering from autoimmune rheumatic diseases have a
significantly increased risk of various infections.
Methods: Our study includes three groups of patients (99 in
total) with stable diseases status, suffering from: 30 patients
with systemic lupus erythematosus (SLE), 37 with rheumatoid
arthritis (RA) and 32 with Sjögren's Syndrome (SjS). 46
patients were immunized with an inactivated trivalent split
vaccine (15 μg HA A/California/7/2009 (H1N1), 15 μg HA A/
Pert/16/2009 (H3N2) and 15 μg / HA B Brisbane / 60/2008)
whereas 52 patients did not accept the proposed vaccination.
These three groups of patients were divided into two
subgroups depending on vaccination: Vaccinated - SLE1 (19),
RA1 (15) and SjS1 (14), and unvaccinated - SLE2 (11), RA2 (22),
SjS2 (18). In the following six months parameters of disease
activity and the titer of antibodies against influenza A H1N1
were monitored. We used hemagglutination inhibition test
(according to the method of the Center for Disease Control
and Prevention (CDC) with antigen A/California/7/2009
influenza virus (H1N1), and turkey erythrocytes for the
detection of antibodies against the A H1N1.
Results: The incidence of viral and bacterial infections among
vaccinated patients was significantly lower, compared to the
non-vaccinated group. Influenza occurrence was significantly
associated with previous respiratory infections (p=0.001). ST
levels for all vaccinated patients (84.17) were significantly
higher than in non-vaccinated patients (8.80) (p=0.008) and
were associated with last vaccination in all patients and in
SLE group (p=0.012, p=0.039 respectively). Seroprotective
rate for all vaccinated patients was 48% compared to 15%
in unvaccinated (p=0.014) and it was highest among SLE
patients (53%) (p= 0.049).
Conclusions: Based on several years of monitoring respiratory
infections in our patients, it is clearly visible that a high risk
for exacerbation of the underlying disease was linked to viral
or bacterial infection and practically never to the vaccination
itself.
Biography:
E-mail:
Ljudmila_Stojanovich@yahoo.comPDF HTML