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Effect of Essential Oils of Citrus sinensis (L.) Osbeck on memory mediated by Acetylcholinesterase inhibition
Joint Event on 12th International Conference on Vascular Dementia and Dementia & 8th International Conference on Neurological Disorders and Stroke
March 14-16, 2019 | London, UK
Yara Maria da Silva Pires, Camila Maria Leal de Moura, Chistiane Mendes Feitosa and Layana Karine Farias Lima
Universidade Federal do Piaui, Brazil
Posters & Accepted Abstracts : J Brain Neurol
Abstract:
Introduction: Alzheimer’s disease (AD) is a chronic
neurodegenerative disorder characterized clinically by the
progressive loss of cognitive function, neuropsychiatric and
behavioral disorders. There are few studies on inhibition of
enzymes linked with AD by plant essential oils (EO), despite its
advantages, such as availability, few side effects or toxicity, and
biodegradability.
Considering the potential of Citrus sinensis (L.) Osbeck to inhibit
acetylcholinesterase (AChE), this research aims to evaluate the
effect of its EO on memory.
Methodology: To assess spatial reference memory, male albino
rats were tested on Morris water maze. The animals were
divided into 5 groups: Control (N=7), EO 50mg/kg (n=6), EO
100mg/kg (n=6) and EO 200mg/kg (n=5). All animals received
oral administration 24h before training. The latency to reach a
hidden platform was recorded.
Results and Discussion: All doses of Citrus sinensis (L.) Osbeck
EO significantly reduced the time to find the platform submerged
in Morris’s water maze test when comparing the control group.
The inhibitory effect of the EO on AChE plays a role in memory
mediation, as well as in cognitive and behavioral function.
AChE inhibitors are currently an important and symptomatic
intervention for AD. Their clinical benefit derive primarily from
an increase in synaptic acetylcholine levels, leading to enhanced
cholinergic neurotransmission which improves activities of daily
living, behavior, and cognitive performance.
Conclusion: The Orange’s EO increase acetylcholine levels and
improve learning and memory impairments. Overall, these
results highlighted essential oil of Citrus sinensis (L.) Osbeck as
a promising and innovative tool in the therapeutic approach to
AD.
Biography:
E-mail:
yara.pires@hotmail.comPDF HTML