Diphoterine solution decontamination of eye/skin chemical exposures: Review and update on recent data
2nd World Congress on TOXICOLOGY AND APPLIED PHARMACOLOGY
November 04-05, 2019 | Prague, Czech Republic
Alan H Hall,Laurence Mathieu
Colorado School of Public Health, USA Laboratoire Prevor, France
Keynote : J Clin Exp Tox
Introduction: Diphoterine is an amphoteric, slightly
hypertonic, polyvalent, sterile water-based eye/skin
decontamination solution which combines passive flushing
with active chemical decontamination. Reviews were
published in French (Minaro et al, 2000) and Hall et al
(2002). Since that time, many more studies of Diphoterine
safety and efficacy, both pre-clinical and clinical, have
been performed. This review describes earlier studies and
details more current ones. Some of these were described in
reviews at the Medichem Conference, Basel, Switzerland,
2016, at the AMPAT Congress, Singapore, 2016, and the
AOHC Congress, Kaohsiung, Taiwan. Presented here are
new not previously presented data.
Materials and Methods: A review of all new data since previous presentations was performed.
Results: Non-Clinical: In vitro/ex vivo comparative decontamination studies with phenol (acid) and tetraammonium hydroxide (TMAH) (base) have been performed. In both cases, Diphoterine solution decontamination was superior to water decontamination. Clinical studies have included a 20-year chemically exposed eye study from Germany in which Diphoterine solution was found better than any other rinsing solution. A multi-center, multinational clinical study from France and Belgium showed the efficacy of Diphoterine solution for decontamination of chemically exposed skin, eyes, and oral membranes in the pre-hospital and emergency department settings. Similar results were found in a clinical study of occupational phenol exposure outcomes in Taiwan and exposure to various various caustic substances in India.
Conclusion: Based on previously published/presented data and data presented here, Diphoterine solution is a better choice than potable water or other rinsing solutions for first aid, pre-hospital, and emergency department (even if delayed) decontamination of chemical eye/skin exposures.
Alan H Hall is a board-certified Medical Toxicologist at Toxicology Consulting and Medical Translating Services, Azle and Springtown, Texas, USA and Clinical Assistant Professor, Colorado School of Public Health, University of Colorado-Denver, Denver, Colorado, USA. Laurence Mathieu is a chemical engineer (ECM) and has a PhD in organic chemistry and catalysis. She is the Head manager of “Scientific Action Group” Department at PREVOR Laboratory.
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