Complicated (ruptured) malignant ovarian Yolk sac tumor in a 7 year old female: A rare case report and literature review

Complicated (ruptured) malignant ovarian Yolk sac tumor in a 7 year old female: A rare case report and literature review

15^th World Congress on Gynecology, Obstetrics and Womens Health & 17^th International Conference on Traditional Medicine and Acupuncture & 9^th World Summit on Cancer Science and Oncology
May 26, 2022 | Joint Webinar

Yasmine El Masry

Tanta University, Egypt

Scientific Tracks Abstracts : Arch Gen Intern Med

Abstract:

Ovarian neoplasms in pediatrics are rare with incidence of 2.6/100.000 girls/year, also ovarian malignancy is even rarer. The germ cell tumors (GCT) are the most common tumor in childhood. They account for 3% of pediatric cancers. Yolk sac tumor (YST) often presents in young women (18-30) years old; ∼33% of YST patients is premenarchal. They account for 3% of pediatric cancers. The incidence frequency of ovarian GCT in the pediatrics is considered to be the highest one (58-70%) if compared with the other ovarian tumors. YST is highly malignant growing rapidly with a very brief duration of symptoms which metastasizes fast to all intraabdominal structures and retroperitoneal lymph nodes. Preoperative diagnosis is difficult, as YST do not have a specific radiological image. YST was universally life-threatening before the combination chemotherapeutic regimens administration which was introduced by the end of 1970s, the 5-year survival rates of YST significantly increased from 14% to nearly 90%. High values of alpha fetoprotein (AFP) orientate strongly to diagnosis of YST. Also, it is a sensible marker for tumor’s evolution; in fact a rapid decrease of serum AFP levels after surgery is a sign of absence of residual tumor and normalization of AFP eflect the efficiency of chemotherapy. The treatment generally involves debulking surgery of tumors followed by systemic chemotherapy, which improved the survival rates dramatically and fertility preserving surgery has become possible. Our review highlights the importance of YST in children, and we provided our valuable experiences in the approaches of diagnosis and treatment for YST in children. We described diagnosis and management of a rare complicated case of YST in a 7-year-old girl.

Biography:

Yasmine El Masry has completed her MD in obstetrics and gynecology at the age of 35 years old from Tanta University, Egypt. She is a lecturer in obstetrics and gynecology department, faculty of medicine, Tanta University.

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