Journal of Brain and Neurology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Alzheimer’s disease and severe cerebral Amyloid Angiopathy; (CAA), CAA related Leukodystrophy leading to synergistic rapidly progressive Dementia

Joint Event on 12th International Conference on Vascular Dementia and Dementia & 8th International Conference on Neurological Disorders and Stroke
March 14-16, 2019 | London, UK

John P Provias

Hamilton Health Sciences, Canada

Posters & Accepted Abstracts : J Brain Neurol

Abstract:

We present an informative case of a female with a rapidly progressive dementing illness clinically, initially thought to represent a form of prion encephalopathy. The patient succumbed to the illness after an approximate two month course and came to a neuro autopsy. Examination of the brain showed no changes of prion disease, but rather typical Alzheimer’s disease neuropathology with a severe cerebral amyloid angiopathy (CAA). No other significant small vessel disease such as hyalinizing arteriosclerosis was present. The severe CAA was widespread, was unassociated with infarction, but lead to a marked generalized secondary leukodystrophy. We emphasize the interrelationship of Alzheimer’s disease and CAA, in particular severe CAA which can produce a vascular based leukodystrophy. This in turn can synergize with and contribute significantly to the dementia. This can contribute to the underlying pathogenesis of the dementia through a white matter disconnection syndrome with acceleration of progression of the Alzheimer-type pathology. Furthermore, the accelerated clinical course due to the synergism can mimic other dementias such as prion disease.

Biography:

E-mail:

[email protected]

PDF HTML