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J u l y 2 3 - 2 4 , 2 0 1 8 | R o m e , I t a l y
Note:
alliedacademies Joint Event on
Cardiology Congress 2018 & Microbe Infection 2018 Biomedical Research | ISSN: 0976-1683 | Volume 29
2nd World Congress on CARDIOLOGY
MICROBIOLOGY AND MICROBIAL INFECTION
&
39th Annual Congress on
Soohong Min et al., Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C1-003
IMPLEMENTATION OF CORONARY ARTERY
PHANTOM WITH HYPEREMIA
Soohong Min1, Cheongah Lee 1, Minho Lee 1, Gwansuk Kang1,
Dong-Guk Paeng1 and Joonhyuk Choi2
1Jeju National University, South Korea
2Jeju National University Hospital, South Korea
Fractional flow reserve (FFR) and coronary flow reserve (CFR) are the
indices to diagnose ischemia in coronary artery diseases. To obtain these
indices, hyperemia, the increased blood flow through vasodilation, is used
as a reference and this occurs when adenosine is injected in vivo. However,
for phantom models in previous studies, most researchers didn’t consider
hyperemia condition. This study aims to implement hyperemia in coronary
artery have constructed a circulation phantomtomimic coronary
flow system. A coronary artery pressure consists of forward and backward
waves. Hyperemia was simulated by the total occlusion of backward flow
when the pressure was decreased, and flow velocity was increased. Doppler
test fluid was used as the flow medium. A reservoir was made to implement
the venous system. To realize the coronary artery stenosis, area ratios of
40%, 70%, and 88% stenosis model were made. The pressure and the flow
velocity inside the tube were measured with a catheter (ComboWire XT,
Philips Volcano, USA). When the mean pressure of the vein was 10 mmHg,
FFR values were 0.93, 0.74, and 0.53 with back flow, and 0.80, 0.63, and 0.42
in hyperemia state, CFR values were 2.2, 1.5 and 1.2 at the stenosis rates of
40%, 70%, and 88%, respectively. When the mean pressure of the vein was
increased to 30 mmHg, FFR values were 0.99, 0.95, and 0.69 with back flow,
and 0.89, 0.85, and 0.59 in hyperemia state, CFR values were 2.5, 1.6 and
1.2 at the stenosis rates of 40%, 70%, and 88%, respectively. We successfully
implemented an in vitro coronary artery system that can measure FFR and
CFR values according to pressure of the vein and the degree of stenosis.
It is expected that phantom model helps to understand the physiology of a
coronary artery diseases.
Soohong Min is pursuing his doctorate from Jeju Na-
tional University in Korea. He is interested in the diag-
nosis and treatment of cardiovascular disease. More
specifically, he is interested in morphological and he-
modynamic information in blood vessels. He is also
interested in medical ultrasonic field.
BIOGRAPHY