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Biotechnology Congress 2018 & Emerging Materials 2018
Biomedical Research
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ISSN: 0976-1683
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Volume 29
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Vega Lloveras et al., Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C4-010
TUNING RADICAL INTERACTIONS IN PPH
RADICAL DENDRIMERS
Vega Lloveras, Flonja Liko, Luiz F Pinto
and
José Vidal Gancedo
Institut de Ciència de Materials de Barcelona ICMAB–CSIC, Spain
T
he spin-spin interactions between unpaired electrons in organic diradicals
and polyradicals are of crucial importance in many areas, such as organic
magnetism, molecular charge transfer, and multiple spin labeling in structural
biology. The flexibility of the scaffold and the length of the linker between
the unpaired electrons is expected to determine the extension of the spin
exchange coupling. Thus, the properties of the scaffold must be carefully
considered, when studying the spin-spin interactions in polyradicals. In
this context, we have turned our attention to dendrimers, whose end-
groups have been coupled to spin probes, allowing their study by electron
paramagnetic resonance spectroscopy (EPR). To discover in what magnitude
the spin exchange coupling could be tuned by changing the properties of
the linker between the radicals and the dendrimer, two generations (G
0
, G
1
)
of polyphosphorhydrazone (PPH) dendrimers were synthesized and fully
functionalized with pendant TEMPO radicals via acrylamido (G
n
-acrylamido-
TEMPO) or imino (G
n
-imino-TEMPO) group linkers. The EPR and cyclic
voltammetry (CV) studies showed that there existed much higher interactions
amongpendant group radicals, whenbounded to the dendrimer by iminogroup
linkers. This was true in either polar or less polar solvents. To conclude, we
were able to drastically change the way that the pendant radicals interacted,
by the solely substitution of the dendritic radical linker.
Vega Lloveras completed her PhD at the Autònoma
University of Barcelona, Spain, in 2006. She has a
permanent position at the Material Science Institute
of Barcelona (ICMAB-CSIC, Spain) in charge of some
spectroscopic equipment like Electron Paramagnetic
Resonance (EPR). She has 40 publications that have
been cited over 1450 times, and her publication H-in-
dex is 18.
vega@icmab.esBIOGRAPHY