Rapid Communication - Journal of Molecular Oncology Research (2022) Volume 6, Issue 4
Submucosal tumor-like oesophageal cancer imitating a cutaneous sweat organ carcinoma.
Department of Pathology and Translational, Research, Gifu University Graduate School of Medicine, Yanagido, Japan
- *Corresponding Author:
- Chiemi Saigo
Department of Pathology and Translational, Research
Gifu University Graduate School of Medicine
Received: 27- Mar -2022, Manuscript No. AAMOR-22- 60523; Editor assigned: 29- Mar-2022, PreQC No. AAMOR -22- 60523 (PQ); Reviewed: 12- Apr-2022, QC No AAMOR -22- 60523; Revised: 18- Apr -2022, Manuscript No. AAMOR -22- 60523 (R); Published: 25- Apr -2022, DOI: 10.35841/aamor-6.4.117
Citation: : Saigo Ch. Submucosal tumor-like esophageal cancer imitating a cutaneous sweat organ carcinoma. J Mol Oncol Res. 2022;6(4):117
Esophageal cancer once in a while develops as an intramural tumor with an intaglio surface epithelium. A past report portrayed submucosal tumor-like oesophageal cancer that had an covering morphological phenotype comparable to that of a cutaneous sweat organ tumor. Here, we experienced another case of submucosal esophageal cancer imitating skin adnexal carcinoma. A man in his early 60s who displayed with trouble in gulping was conceded to our healing center. He had a 30 × 30 mm submucosal tumor within the stomach esophagus and experienced halfway esophagogastrectomy. Histopathological examination uncovered that the tumor was composed of cord-like squamoid cell homes that was in part accompanied by organ structure within the inward layer, as found in cutaneous squamoid ductal eccrine carcinoma.
Esophageal cancer, Esophageal submucosal gland, SMT-like tumor
Esophageal cancer as a rule appears mucosal cancerous injuries, encouraging histopathological conclusion through endoscopic examination. In specific, progressed esophageal cancers commonly show as masses or ulcerations. Be that as it may, esophageal cancer once in a while develops as an intramural tumor with an nearly intaglio surface epithelium. Within the English writing, McGregor et al. to begin with detailed intramural esophageal cancer . since at that point, a few case reports have depicted intramural esophageal cancers with small or no modified shallow stratified squamous epithelium. There are moreover clinicopathological considers with collected cases of intramural esophageal cancer, counting a trial think about to separate intramural esophageal cancer from submucosal mesenchymal tumor by endoscopic ultrasonography. Interests, there's a report portraying SMTlike esophageal cancer with a cutaneous sweat organ tumorlike phenotype . In this, we report a case of SMT-like esophageal cancer imitating a sweat organ tumor of the skin. The tumor shown an organoid structure composed of cordlike squamoid homes, with glandular components within the squamoid homes. These histopathological highlights cover with those of cutaneous sweat organ carcinoma, that's, squamoid eccrine ductal carcinoma. The plausibility of esophageal submucosal gland duct root is additionally examined in a audit of some past case reports. A man in his early 60 s who displayed with gulping troubles since a few month was at last conceded to our clinic since of sickness and spewing. He had no restorative history of a threatening tumor. Endoscopic examination uncovered a marginally raised injury, such as a SMT, within the stomach esophagus. Examination of endoscopic biopsy examples from the injury uncovered a non-dysplastic esophageal mucosa. Within the submucosal tissue, unpredictably molded widened ductal components were went with by tumor cell homes. Immunohistochemical recoloring illustrated that the organ structure of the tumor shown solid CK7 immunoreactivity, which was utilized to recognize esophageal submucosal organ conduits as well as neighboring hyperplastic expanded ductal cells .
Tumor homes were composed of an external p63-positive squamous cell layer, and the organ structure was positive for carcinoembryonic antigen. But for the furthest cell layer, the tumor cells shown CK7 immunoreactivity. In expansion, immunoreactivity to the glucose cotransporter family protein SLC5A5 was too found in tumor cells. Outstandingly, desmoglein 3 immunoreactivity highlighted the intercellular bridging of squamoid tumor cell homes. The display tumor moreover illustrated clear cell changes within the tumor settle and perineural attack, which have been detailed in cutaneous squamoid eccrine channel carcinoma . These histopathological highlights indicated that the tumor may well be an SMT-like esophageal carcinoma mirroring cutaneous sweat organ tumor. Eminently, a few esophageal submucosal organs, which illustrated metaplastic changes, were found adjoining to the tumor . Taking the highlights of strong CK7 immunoreactivity, closeness to the conduit structure, and expanded esophageal organ conduit adjoining to the tumor, the display tumor is likely to be inferred from conduits of the esophageal submucosal organs. In expansion, the display tumor moreover shown immunoreactivity with antibodies.
- Endoh Y, Miyawaki M, Tamura G, et al.Esophageal adenocarcinoma that probably originated in the esophageal gland duct: A case report. Pathol Int. 1999;49(2):156-59.
- van der Horst MP, Garcia-Herrera A, Markiewicz D, et al. Squamoid eccrine ductal carcinoma: A clinicopathologic study of 30 cases. Am J Surg Pathol. 2016;40(6):755-60.
- von Rahden BH, Brücher BL, Sarbia M, et al. Esophageal squamous cell carcinoma with entirely intramural growth pattern. Virchows Arch. 2006;448(6):862-66.
- Sonthalia N, Jain SS, Surude RG, et al. Primary esophageal intramural squamous cell carcinoma masquerading as a submucosal tumor: a rare presentation of a common disease. Clin Med Insights Gastroenterol. 2016;9:63-66.
- Tamura H, Saiki H, Amano T, et al. Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report. World J Gastroenterol. 2017;23(21):3928-33.