Opinion Article - Journal of Brain and Neurology (2022) Volume 5, Issue 6
Role and functions of neurodevelopment in spinal cord injury.
Department of Medicine, Fudan University, china.
- *Corresponding Author:
- Syed Hashmi
Department of Medicine,
Received:24-Oct-2022, Manuscript No. AAJBN-22-82150; Editor assigned: 28-Oct-2022, PreQC No. AAJBN-22-82150(PQ); Reviewed:11-Nov-2022, QC No. AAJBN-22-82150; Revised:15-Nov-2022, Manuscript No. AAJBN-22-82150(R); Published:21-Nov-2022,DOI:10.35841/aajbn-5.6.127
Citation: Hashmi S. Role and functions of neuro development in spinal cord injury. J Brain Neurol. 2022;5(6):127
The spinal cord plays a role in the transmission pathway information transmission between the brain and the peripheral nervous system. It is the complex arrangement of patterns and connections makes visualization difficult. From its small cross-sectional area and location body. However, significant advances in imaging technology. It has arisen over the past decade and has improved resolution, allowing better assessment of this more detailed anatomy.
Cellular transplantation, Electrophysiology.
Precise control of neural progenitor cell proliferation and differentiation is critical for central nervous system development. Fusion in Sarcoma (FS) is an RNA-binding protein pathogenically associated with Amyotrophic Lateral Sclerosis (ALS) and Frontal Temporal Oar Degeneration (FTOD) but the role of FUS in neurodevelopment is yet to be defined. Here we report a pivotal role for FUS in regulating human cortical brain and spinal cord development via human derived organics. We found that CRISPR/CAS9-mediated FUS depletion leads to enhanced neuronal proliferation and differentiation in cortical brain organics .
Interestingly however these phenotypic impairments in spinal cord organics. In addition FUS binds to [Trk] Tyrosine Kinase receptor mRNA for neurotropic (Ntrk3) and regulates the expression of different is forms of Ntrk3 in a tissue-specific manner. Finally RNA-mediated reduction of NTRK3 levels rescued the effects of her FUS on the development of brain and spinal cord organics suggesting that Ntrk3 is involved in developmental changes in her FUS-regulated organic. Our results revealed a role in neurodevelopment of the human central nervous system. Spinal Cord Injury (SCI) is a debilitating injury of the central nervous system with complex pathological mechanisms leading to sensory and motor dysfunction. Current treatments for spinal cord injury are aimed at symptomatic relief rather than pathological causes. Several studies have reported that signalling pathways play an important role in the pathological process of his SCI and neuronal recovery mechanisms. The PI3K/Akt signalling pathway is a key pathway closely related to the pathological process of SCI, and activation of this pathway slows the inflammatory response, prevents glial scar formation, and promotes recovery of neuronal function .
Spinal Cord Injury (SCI) is a debilitating injury of the central nervous system with complex pathological mechanisms leading to sensory and motor dysfunction. Current treatments for spinal cord injury are aimed at symptomatic relief rather than pathological causes. Several studies have reported that signalling pathways play an important role in the pathological process and neuronal recovery mechanisms. The PI3K/Akt signalling pathway is a key pathway closely related to the pathological process of SCI, and activation of this pathway slows the inflammatory response prevents glial scar formation and promotes recover. Activation of this pathway may facilitate recovery of neuronal function after SCI by reducing cell apoptosis. Based on the role of her PI3K/Akt pathway in spinal cord injury, this could be a potential therapeutic target.This review highlights the role of activation or inhibition of the PI3K/Akt pathway in SCI-induced inflammatory responses, apoptosis, autophagy and glial scar formation. We also summarize the latest insights into the treatment of spinal cord injury by targeting the PI3K/Akt pathway, discuss the shortcomings and deficiencies of PI3K/Akt research in spinal cord injury, and discuss the potential in developing clinical therapeutic strategies for these spinal cords. Identify and deliver relevant challenges suitable of neuronal function .
According to the latest World Health Organization (WHO) report approximately million people worldwide suffer from SCI, and the global incidence of SCI is estimated at per year Due to the reduced ability of autonomic nerve repair after spinal cord injury and the rapid onset of various pathological processes, the injured spinal cord cannot easily undergo tissue repair and reconstitution of function. Therefore, neurological recovery after SCI is a difficult issue in the medical community. Although many studies have been conducted on the molecular and cellular mechanisms of SCI the exact pathophysiological mechanisms of SCI are still unknown due to the lack of a comprehensive understanding of the pathological processes and mechanisms associated with SCI. is However, current SCI treatment focuses primarily on symptom palliation rather than pathophysiological interventions.Therefore, improving our understanding of its pathogenesis and identifying key molecular therapeutic targets are essential for effective treatment of SCI [4,5].
In the acute phase spinal cord ischemia, edema, inflammation, and free radical-mediated peroxidation mainly occur In the sub-acute phase, vascular system destruction and neuronal apoptosis mainly occur The main characteristics of chronic SCI are axon tip blight cystic cavity, and glial scarring, which inhibit axonal growth and regeneration. The pathophysiology of SCI involves a series of interrelated events, such as vascular ischemia, hypovolemic, excitotoxicity, cytotoxicity, cacogenic edema, ion homeostasis imbalance, and mitochondrial dysfunction.
- Sloan SA, Barres BA.Mechanisms of astrocyte development and their contributions to neurodevelopmental disorders.. Curr Opin Neurobiol. 2014;27:75-81.
- Rigby MJ, Gomez TM.Glial cell-axonal growth cone interactions in neurodevelopment and regeneration..Front Neurosci. 2020;14:203.
- Srejovic I, Selakovic D.Galectin-3: roles in neurodevelopment, neuroinflammation, and behavior..Biomolecules. 2020;10(5):798.
- Zhou Y, Wang Z.Fibroblast growth factors in the management of spinal cord injury. J Cell Mol Med 2018;22(1):25-37.
- Wu LJ, Stevens BMicroglia in neuronal circuits..Neural Plast. 2022;37(1-3):184-207.