Insights in Nutrition and Metabolism

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Mini Review - Insights in Nutrition and Metabolism (2022) Volume 6, Issue 5

Exercise physiology: pathophysiology, metabolism and clinical significance.

Ronald Dawson*

Department of Sport and Exercise Science, Loughborough University, England, United Kingdom

*Corresponding Author:
Ronald Dawson
Department of Sport and Exercise Science
Loughborough University, England, United Kingdom

Received: 06-Sep-2022, Manuscript No. AAINM-22-74445; Editor assigned: 07-Sep-2022, PreQC No. AAINM-22-74445(PQ); Reviewed: 20-Sep -2022, QC No. AAINM-22-74445; Revised: 24-Sep-2022, Manuscript No. AAINM-22-74445(R); Published: 29-Sep-2022, DOI: 10.35841/aainm-6.5.124

Citation: Dawson R. Exercise physiology: Pathophysiology, metabolism and clinical significance. Insights Nutr Metab. 2022;6(5):124

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Contrasted with our resting state, exercise represents a significant demand increases for the body. At rest, our nervous system keeps a parasympathetic tone, which influences the respiratory rate, heart output, and different metabolic cycles. Exercise stimulates the sympathetic nervous system and will prompt a coordinated response from the body; This response attempts to keep a fitting degree of homeostasis for the expanded interest in physical, metabolic, respiratory, and cardiovascular efforts.



Metabolic, Respiratory, Cardiovascular.


Issues of concern

Cardiovascular disease stays a pervasive issue in our patient populace in spite of advances in counteraction rules and therapies. The top gamble factors incorporate hypercholesterolemia, hypertension, diabetes, obesity, and tobacco use; these referenced risk factors envelop almost half of the mortality division. Absence of exercise will in general worsen the deleterious impacts of these risk factors while executing practice in day to day schedule has been displayed to lessen death rates. In particular, the absence of exercise is straightforwardly connected to obesity, while likewise assuming a part in the development of diabetes and hypertension.

Research demonstrates the way that activity, related to other way of life alterations, can decrease the risk of hypertension paying little mind to inborn hereditary inclinations; additionally, practice has displayed to increment insulin awareness in the administration way to deal with diabetes.

Healthy body weight can be achieved through way of life adjustments to additionally diminish mortality because of cardiovascular sickness.

With exercise being a non-invasive and non-pharmaceutical intervention, it plays a pivotal part in regards to accessibly and working on personal satisfaction [1].


The body must convert adenosine triphosphate into energy in order for muscles to contract. The state of the body affects how muscles maintain their ATP levels.

Both aerobic and anaerobic methods of using glucose or glycogen are available to muscles. Particularly in the anaerobic environment, the glycolytic energy system frequently results in lactate buildup and a subsequent fall in pH in muscle tissue.

While anaerobic metabolism takes part in a high-intensity activity like weightlifting, aerobic metabolism is often used during workouts like walking.

The oxidative phosphorylation pathway, a component of the aerobic system that takes place on the inner mitochondrial membrane and generates significantly more ATP than other metabolic pathways, is the primary source of ATP for cells [2].

The significant wellspring of ATP for cells is through the oxidative phosphorylation pathway; this is important for the high-impact pathway that happens on the inward mitochondrial film and creates considerably more ATP than other metabolic pathways.

Complex I: Receives electrons from NADH.

Complex II: receives electrons from succinate; coenzyme Q10 transfers the electrons from NADH and succinate to complex III.

Complex III: Cytochrome C transports the electrons from this location to complex IV.

Complex IV: At this subunit, oxygen accepts electrons, creating water.

Complex V: When the protons return to the gradient of the electrons, ATP is produced.

Muscles burn through ATP very quickly during high-intensity activities like high-intensity interval training or intense weight training, creating a pool of ADP as a result. Muscle energy is provided through the donation of a phosphate group by phosphocreatine to ADP in order to regenerate more ATP. This process is catalysed by creatine kinase.

Muscles can use fatty acids as fuel sources whether at rest or performing low-intensity exercise.

The mitochondrial matrix engages in beta-oxidation of mediumchain fatty acids. Carnitine is needed for the transfer of longchain fatty acids from the cytosol to the mitochondria [3].

The axon terminal of a motor unit releases the neurotransmitter acetylcholine onto sarcolemma receptors in response to an excitation signal. In order to conduct a coordinated signal deep inside the muscle, this signal activates voltage-gated channels and generates an action potential that travels along the T-tubules. The sarcoplasmic reticulum will release its calcium ions when that depolarization reaches it.

The actin-binding site on myosin is unblocked by tropomyosin when these calcium ions are released because they bind to troponin C in the sarcoplasm. In essence, calcium binds to troponin, causing tropomyosin to dissociate by exposing the actin-myosin binding site, actin and myosin can now attach to each other, producing a contractile force that shortens the sarcomere unit. The contraction is brought about by the myosin head, which hydrolyzes ATP into ADP and phosphate. Myosin must bind to ATP in order to relax from the contracted state, which releases the actin site and returns myosin to its high energy state. The sliding filament idea, according to which actin and myosin filaments glide past one another to reduce the length of the sarcomere, can explain this shortening and lengthening model. The many forms of muscular contractions are numerous [4].

Isometric contraction: Active contraction of the muscle without lengthening caused to opposing forces acting with equal and opposite polarities.

holding a plank position or carrying groceries while holding an arm bent at the elbow.

Concentric contraction: The muscle actively contracts and shortens itself as a result of a stronger muscle force than an opposing force that comes close to the muscle's attachment and origin.

Bench press, bicep curls with dumbbells, and squats

Eccentric contraction is when a muscle actively contracts while also lengthening; it does so with less force than the opposing force.

The above-mentioned exercise's "negative" component

The lowering component of a bench press, the lowering section of a bicep curl, and the lowering portion of a row squat from remaining to a squat position.


  1. Abdin S, Lavallee JF, Faulkner J, et al. A systematic review of the effectiveness of physical activity interventions in adults with breast cancer by physical activity type and mode of participation. Psychooncol. 2019;28(7):1381-93.
  2. Indexed at, , Google scholar, Cross ref

  3. van Rijckevorsel-Scheele J, Willems RCWJ, Roelofs PDDM, et al. Effects of health care interventions on quality of life among frail elderly: a systematized review. Clin Interv Aging. 2019;14:643-58.
  4. Indexed at, , Google scholar, Cross ref

  5. Young C, Campolonghi S, Ponsonby S, et al. Supporting Engagement, Adherence, and Behavior Change in Online Dietary Interventions. J Nutr Educ Behav. 2019;51(6):719-39.
  6. Indexed at, , Google scholar, Cross ref

  7. Kramer SF, Hung SH, Brodtmann A. The Impact of Physical Activity Before and After Stroke on Stroke Risk and Recovery: a Narrative Review. Curr Neurol Neurosci Rep. 2019;19(6):22-8.
  8. Indexed at, Google scholar, Cross ref

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