Journal of Molecular Oncology Research

Reach Us +44 7460731551

Opinion Article - Journal of Molecular Oncology Research (2022) Volume 6, Issue 5

Essential intraventricular Glioblastoma GBM: Case report and audit of writing.

Baheddin Muhsen*

Department of Surgery, King Hussein Cancer Center, Amman, Jordan

*Corresponding Author:
Baheddin Muhsen
Department of Surgery
King Hussein Cancer Center
Amman
Jordan
E-mail: [email protected]

Received: 27-Apr-2022, Manuscript No. AAMOR-22-62600; Editor assigned: 29-Apr-2022, Pre QC No. AAMOR-22-62600(PQ); Reviewed: 14-May-2022, QC No. AAMOR-22-62600; Revised: 20-May-2022; AAMOR-22-62600(R); Published: 27-May-2022, DOI: 10.35841/aamor-6.5.123

Citation: Muhsen B. Essential intraventricular Glioblastoma GBM: Case report and audit of writing. J Mol Oncol Res. 2022;6(5):123

Visit for more related articles at Journal of Molecular Oncology Research

Abstract

Glioblastoma multiforme (GBM) is the foremost common essential central apprehensive framework tumor. The frontotemporal area is the foremost common area for the event of GBM, in any case, the event of this injury within the intraventricular framework is very rare and as it were some cases have been detailed approximately it within the writing. We display another case of essential intraventricular GBM of a 61-year-old understanding with a point by point portrayal of the clinical introduction, neuro-radiological and obsessive discoveries, and the surgical approach to the tumor. We surveyed cases of essential intraventricular glioblastomas within the writing and concluded that it is exceptionally uncommon and has destitute guess. Surgical net debulking and the degree resection are exceptionally vital variables that influence the forecast of GBM patients. Intraventricular GBM is an forceful tumor with a challenging area that's ordinarily related with a destitute guess. In any case, our persistent appeared a long-term survival of 78 months.

Keywords

GBM, Glioblastoma, Intraventricular location, Good outcome, High grade glioma.

Introduction

One of the foremost common essential brain tumors constituting 25% of all intracranial tumors in grown-ups is Glioblastoma multiforme. GBM is known as the foremost threatening essential brain tumor and can be found anyplace inside the central nervous framework (CNS) but they regularly display within the frontotemporal locale of the cerebral cortex. The ventricular framework may be an exceptionally uncommon area for the occurrence of GBM and there are a number of cases detailed within the writing that conclude that this specific area contains a more regrettable guess than other areas [1]. We report a case of intraventricular Glioblastoma in arrange to examine the clinical and radiological discoveries of this tumor. This paper has been detailed in line with the Alarm criteria. A 61-year-old understanding displayed to our clinic with a migraine, foggy vision, and shaky stride. The quiet had a past therapeutic history of diabetes mellitus and dyslipidemia. On examination, there was papilledema, misfortune of pair stride and left-sided shortcoming with a 4/5 on the control appraisal scale. A brain MRI with differentiate was done and it appeared an improving injury within the third ventricle with expansion to right lateral ventricle through the proper foramen of Monro. A coronal see without differentiate appeared a hypo-intense injury and a expanded right horizontal ventricle.

A liquid weakened reversal recuperation was moreover done and it appeared peri-ventricular interstitial edema around the frontal and occipital horns. The understanding experienced a right frontal craniotomy transcortical approach with neartotal resection in 2015. The surgery was performed by Dr. Amer Shurbaji. Histopathological examination of the tumor appeared palisading rot with encompassing expansion of harmful astrocytes which the tumor is composed of expansion of dangerous astrocytes with atypical cores and irregular mitotic figures. Besides, most of the tumor cells were positive for the GFAP immunostain and the atypical tumor cells were positive for P53 immunostatin. The persistent gotten Temozolamide as adjuvant treatment and completed six cycles of it radiation treatment as 55Gy/25fx. The patient's postoperative evaluation was uneventful. He had intaglio cranial nerves with great sensation and control of the appendages (review V on appraisal). Postoperative brain MRI with differentiate appeared close add up to resection of the exophytic mass with remaining little center of differentiate improvement. In this case we depict a common essential brain tumor with a bizarre area.

The regular area for GBM is the cerebral sides of the equator [2]. Glioblastomas are classified as tall review astrocytomas. These are forceful tumors that show noteworthy mass impacts, edema, corruption and hemorrhage on radiographic imaging. In spite of the fact that GBM is the foremost common deadly essential central anxious system tumor in grown-ups, many cases of intraventricular GBM were detailed in childhood and adolescences, Which may be an exceptionally uncommon area for this tumor. Pediatric GBM was found to have distant better;a much better;a higher;a stronger;an improved">a distant better guess compared to its grown-up partner. The intraventricular area of this tumor has been connected to more awful forecast compared with its other areas. Histopathologically, glioblastomas are ordinarily hypercellular conjointly appear cellular pleomorphism and necrosis. Essential intraventricular Glioblastomas start from the ventricular divider or from the structures inside the ventricle [3].

In any case, tumors that start from structures near to the ventricles and exophytically develop into them are considered auxiliary ventricular tumors. We report a case of intraventricular Glioblastoma with close add up to resection taken after by chemotherapy and radiotherapy sessions. Our persistent appeared change postoperatively and was taken after up for 78 months after surgery demonstrating long-term survival. We have too summarized the characteristics of essential Intraventricular tall review gliomas and glioblastomas detailed within the writing alongside their mode of administration and length of survival. Attractive reverberation imaging is the commonly utilized way to analyze and identify the beginning of the injury which can offer assistance in choosing the treatment [4]. Unpredictable borders and heterogeneous or ring-like differentiate improvement seen in an MRI more often than not show in Intraventricular GBMs. Besides, a wide encompassing edema on T2-weighted pictures and central hypointensity as a rule show corruption.

Our patient's radiographical introduction appeared an upgrading injury within the third ventricle amplifying to the sidelong ventricle, hypointense injury and a widened right horizontal ventricle. Surgical net debulking and the degree resection are exceptionally critical variables that influence the forecast of GBM patients. Net debulking not at all like negligible resection or biopsy has been appeared to extend the length of survival and quality of life of GBM patients.

Other variables that impact a longer survival and superior quality of life are radiotherapy with adjuvant chemotherapy. Early randomized considers appeared a critical increment in survival in patients who were given radiotherapy after surgical resection. The profound situated GBM is some of the time treated with laser interstitial warm treatment or stereortactic radiosurgery. Additionally, another ponder found that Gamma Cut radiosurgery can be utilized within the administration of select cases particularly in patients who are destitute surgical candidates. The treatment of intraventricular GBMs as a rule depends on the measure and area of the tumor. Be that as it may, the point of the surgery is more often than not to extend the length of survival as well as the quality of life of the patients [5].

References

  1. Sarikafa Y, Akçakaya MO, Sarikafa S, et al. Intraventricular glioblastoma multiforme: Case report. Neurocirugia. 2015;26(3):147-50.
  2. Indexed at, Google Scholar, Cross Ref

  3. Agha RA, Franchi T, Sohrabi C, et al. The Scare 2020 guideline: Updating consensus surgical Case report (SCARE) guidelines. Int J Surg. 2020;84:226-30.
  4. Indexed at, Google Scholar, Cross Ref

  5. Secer HI, Dinc C, Anik I, et al. Glioblastoma multiforme of the lateral ventricle: Report of nine cases. Br J Neurosurg. 2008;22(3):398-401.
  6. Indexed at, Google Scholar, Cross Ref

  7. Nitta N, Moritani S, Fukami T, et al. Intraventricular epithelioid glioblastoma: A case report. World Neurosurg. 2018;112:257-63.
  8. Indexed at, Google Scholar, Cross Ref

  9. Sharma M, Schroeder JL, Elson P, et al. Outcomes and prognostic stratification of patients with recurrent glioblastoma treated with salvage stereotactic radiosurgery. J Neurosurg. 2018;131(2):489-99.
  10. Indexed at, Google Scholar, Cross Ref

Get the App