Insights in Nutrition and Metabolism

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Commentary - Insights in Nutrition and Metabolism (2023) Volume 7, Issue 5

Epigenetics and obesity: Factors behind weight gain.

Francine Howard*

Department of Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain

*Corresponding Author:
Francine Howard
Department of Food Sciences, Physiology and Toxicology
University of Navarra
Pamplona, Spain

Received:29-Aug-2023,Manuscript No. AAINM-23-112860; Editor assigned: 01-Sept-2023, PreQC No. AAINM-23-112860(PQ); Reviewed:15-Sept-2023, QC No. AAINM-23-112860; Revised:20-Sept-2023, Manuscript No. AAINM-23-112860(R); Published:28-Sept-2023, DOI: 10.35841/aainm- 7.5.168

Citation: Howard F. Epigenetics and obesity: Factors behind weight gain. Insights Nutr Metab. 2023;7(5):168

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Obesity has become a global epidemic, affecting millions of people across the world and posing a significant public health challenge. While lifestyle factors such as diet and physical activity play a crucial role in the development of obesity, recent research has shed light on the role of genetics and epigenetics in this complex condition. Epigenetics, the study of heritable changes in gene expression that do not involve alterations to the underlying DNA sequence, has emerged as a fascinating field of research with profound implications for our understanding of obesity. This article delves into the intricate relationship between epigenetics and obesity, exploring how epigenetic modifications can contribute to weight gain and its associated health consequences.

Role of genetics in obesity

Numerous studies have identified specific genetic variants that are associated with an increased risk of obesity. These genetic predispositions can affect an individual's metabolism, appetite regulation, and fat storage, making them more susceptible to weight gain. However, the genetic aspect of obesity is only part of the puzzle. Epigenetics introduces a new layer of complexity to this equation.

Epigenetics: A primer

Epigenetics involves heritable changes in gene expression that occur without altering the underlying DNA sequence. These changes can be influenced by various factors, including environmental exposures, lifestyle choices, and even stress. Epigenetic modifications can silence or activate genes, influencing an individual's susceptibility to various diseases, including obesity[1].

Epigenetics and Obesity

DNA methylation: One of the most well-studied epigenetic modifications in the context of obesity is DNA methylation. DNA methylation involves the addition of a methyl group to a cytosine base within the DNA sequence, typically occurring at CpG sites (cytosine followed by guanine). These methyl groups can silence gene expression.

The changes in DNA methylation patterns are associated with obesity. For example, genes involved in appetite regulation and energy metabolism may undergo abnormal methylation patterns in obese individuals. This can lead to dysregulated gene expression, contributing to weight gain and obesity-related complications.

Histone modifications: Histones are proteins that package and organize DNA into a compact structure called chromatin. Chemical modifications to histones can influence the accessibility of DNA, thereby affecting gene expression. Specific histone modifications, such as acetylation and methylation, have been implicated in obesity-related pathways.

For instance, histone acetylation is associated with active gene expression. In obese individuals, alterations in histone acetylation patterns in genes related to adipogenesis (the process of fat cell formation) can promote excessive fat storage. This highlights the importance of epigenetic regulation in the development of obesity.

Non-Coding RNAs: Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are another critical component of the epigenetic machinery. These molecules can influence gene expression by binding to messenger RNAs (mRNAs) and either promoting their degradation or inhibiting their translation into proteins.

In the context of obesity, certain miRNAs have been identified as key regulators of adipogenesis and fat metabolism. Dysregulation of these miRNAs can lead to abnormal fat accumulation and obesity[2].

Environmental Factors and Epigenetic Changes

While genetics can influence an individual's predisposition to obesity, epigenetic changes can be modulated by environmental factors. This intersection between genetics, epigenetics, and the environment is particularly relevant to obesity.

Diet: Diet plays a pivotal role in epigenetic modifications associated with obesity. Consuming a high-calorie, low-nutrient diet can lead to changes in DNA methylation and histone modifications, promoting the development of obesity. For example, excessive intake of sugar and saturated fats can induce epigenetic changes in genes related to metabolism and appetite regulation.

Conversely, a healthy diet rich in fruits, vegetables, and whole grains may have a protective effect by promoting beneficial epigenetic modifications. This emphasizes the significance of dietary choices in obesity prevention.

Physical activity: Physical activity can also modulate epigenetic changes related to obesity. Regular exercise has been shown to influence DNA methylation patterns, particularly in genes involved in energy metabolism and fat oxidation. These changes can enhance an individual's ability to maintain a healthy weight and reduce the risk of obesity.

Early life experiences: Epigenetic changes can occur early in life and have lasting effects on an individual's susceptibility to obesity. Adverse experiences during prenatal development, infancy, and childhood can induce epigenetic modifications that increase the risk of obesity in adulthood. This concept, known as developmental programming, highlights the importance of early interventions and a nurturing environment in preventing obesity[3].

Epigenetics and obesity-Related health consequences

Obesity is not only about carrying excess weight; it is also associated with a host of health complications, including type-2 diabetes, cardiovascular diseases, and cancer. Epigenetics can shed light on the molecular mechanisms underlying these obesity-related health consequences.

Type-2 Diabetes: Epigenetic modifications can influence insulin sensitivity and glucose metabolism. Aberrant DNA methylation and histone modifications in genes related to insulin signaling can lead to insulin resistance, a hallmark of type 2 diabetes. Understanding these epigenetic changes may open new avenues for diabetes prevention and treatment.

Cardiovascular diseasee: Obesity is a major risk factor for cardiovascular diseases such as hypertension and atherosclerosis. Epigenetic alterations in genes involved in blood pressure regulation and lipid metabolism can contribute to these conditions. Identifying and targeting these epigenetic changes may offer novel approaches to cardiovascular disease prevention.

Cancer: Obesity is linked to an increased risk of certain cancers, including breast, colon, and pancreatic cancer. Epigenetic modifications in genes controlling cell proliferation and DNA repair may play a role in cancer development. The epigenetic mechanisms underlying obesity-related cancer risk can inform cancer prevention strategies[4].

The potential for epigenetic interventions

The discovery of epigenetic changes associated with obesity opens the door to potential interventions. While lifestyle modifications, such as diet and exercise, remain crucial for obesity prevention and management, targeting epigenetic modifications may offer additional therapeutic avenues.

Epigenetic drugs: Pharmaceutical companies are actively researching epigenetic drugs that can modify DNA methylation and histone modifications. These drugs, known as epigenetic modifiers, have the potential to reverse harmful epigenetic changes associated with obesity and its complications.

Personalized medicine: Epigenetic profiling may enable personalized approaches to obesity prevention and treatment. Identifying an individual's unique epigenetic signature could help tailor interventions to address their specific epigenetic vulnerabilities.

Early interventions: The epigenetic changes that occur early in life can inform early interventions to reduce the risk of obesity. Prenatal and childhood interventions that promote healthy epigenetic patterns may have a lasting impact on obesity prevention[5].


Epigenetics has illuminated the intricate relationship between genetics, the environment, and obesity. The epigenetic modifications associated with obesity shed light on the molecular underpinnings of this complex condition and its associated health consequences. While genetics may predispose individuals to obesity, epigenetics provides a dynamic framework through which lifestyle choices and environmental factors can influence gene expression and obesity risk. The growing field of epigenetics holds promise for the development of innovative approaches to obesity prevention and treatment. From epigenetic drugs to personalized interventions, researchers are exploring a range of strategies to harness the power of epigenetic modifications in the fight against obesity. However, ethical and societal considerations must guide the responsible use of epigenetic knowledge to address this global health challenge.


  1. Keller M, Hopp L, Liu X, et al.Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity.Mol Metab. 2017;6(1):86-100.
  2. Indexed at, Google Scholar, Cross Ref

  3. Guenard F, Tchernof A, Deshaies Y, et al.Genetic regulation of differentially methylated genes in visceral adipose tissue of severely obese men discordant for the metabolic syndrome.Transl Res. 2017;184:1-1.
  4. Indexed at, Google Scholar, Cross Ref

  5. Johansson LE, Danielsson AP, Parikh H, et al.Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance.Am J Clin Nutr. 2012;96(1):196-207.
  6. Indexed at, Google Scholar,Cross Ref

  7. Rosso N, Chavez-Tapia NC, Tiribelli C, et al.Translational approaches: From fatty liver to non-alcoholic steatohepatitis.World J Gastroenterol. 2014;20(27):9038.
  8. Indexed at, Google Scholar, Cross Ref

  9. Bonnefond A, Raimondo A, Stutzmann F, et al.Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features.J Clin Invest. 2013;123(7):3037-41.
  10. Indexed at, Google Scholar, Cross Ref

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