Review Article - Archives of General Internal Medicine (2021) Volume 5, Issue 7
The role of gut microbiome in cardiometabolic disease.
The study of the human microbiota has recently emerged as an area of utmost importance. The human gut microbiome consists of trillions of microorganisms that outnumber human cells and play a vital role in host metabolism. Obesity is a risk factor for cardiometabolic disease (CMD), which includes type 2 diabetes mellitus (T2DM), dyslipidemia, hypertension, cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). Recent studies have shown a connotation between microbiota and CMD. Studies have established that the gut microbiota is one of the crucial factors, which influence the metabolic state of the host and acts as a propeller for the disease. In this review, we focus on the recent findings on the dysbiosis of gut microbiota and CMD pathogenesis and future therapeutic intervention involving gut microbiome manipulation.Author(s): Ashwini Kumar Ray*, Urvinder S. Kaur, Jyoti Gupta, Alka Yadav, Tannu Bhagchandani, Alok kumar singh, Shalimar, Ravi Tandon*, Rupesh Chaturvedi*