Research Article - Biomedical Research (2019) Volume 30, Issue 1
Testing different concentrations of both hydrocortisone and rifampicin toward pregnane X receptor activation suggest their protective effect against liver toxicity.
In different animal and human (in vitro) models, PXR activation resulted in suppressed liver inflammation and fibrosis which in return suggest graft survival. In this study, different concentrations of hydrocortisone (HC) and rifampicin were tested for PXR activity. For each drug, transfected HEPG2 cells were treated with different molar concentrations and then luciferase activity for both firefly and renilla were recorded. Both hydrocortisone and rifampicin produced an increase in PXR activity. Correlation between PXR activation and graft failure must be addressed in clinical settingAuthor(s): Elham Alshammari