Journal of Medical Oncology and Therapeutics

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1-845-458-6882

Research Article - Journal of Medical Oncology and Therapeutics (2018) Volume 3, Issue 2

Survival of patients with advanced NSCLC treated with first-generation EGFR-TKIs at a cancer hospital in Thailand, 2011-2016.

Objective: The present study was to determine survival of the patients with advanced Non-Small Cell Lung Cancer (NSCLC) treated with Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors (EGFR-TKIs) at Chonburi Cancer Hospital (CCH). Material and Methods: The study was conducted retrospectively by review of medical records of stage IIIB-IV NSCLC patients treated with first-generation EGFR-TKIs at CCH from January, 2011- December, 2016. Results: The present study enrolled 50 patients with median follow up time 16.78 months. The median age of patients was 58.5. There were female (46%), non-smoking (62%) and adenocarcinoma (90%). The sources of EGFR-TKI were a reimbursement system (32%), purchase for themselves (52%) and free drug samples (14%). Eastern Cooperative Oncologic Group (ECOG) performance status was 0-1 (54%), 2-4 (28%) and Non-Available (NA) (18%). The median Overall Survival (OS) of all patients were 17.18 months. The OS of the patients receiving EGFR-TKIs as first-line or maintenance (n=18), second-line (n=18) and third-line or more (n=14) were 15.86 (95%CI, 10.26-21.46), 10.87 (95%CI, 0.00-28.29) and 20.23 (95%CI, 6.26-34.21) (p=0.392) months, respectively. Regarding EGFR status, the OS of patients with EGFR sensitizing-mutation (22%), wild-type (12%) and unknown (66%) were 30.75 (95% CI,13.76-47.74), 7.91 (95% CI, 0.00-20.45) and 13.99 (95%CI, 9.17-18.82) (p=0.086) months, respectively. Multivariate analysis indicated that smoking (p=0.006), ECOG performance status 2-4 and NA (p<0.001), receiving EGFR-TKIs by payment (p=0.040) and compassionate use (p<0.001) were the unfavorable prognostic factors for the OS. Conclusion: In spite of the fact that most of the patients started an EGFR-TKI before their EGFR status was confirmed and often received it as a second-line or more. The OS of patients harbouring EGFR sensitizing-mutation in the present study was comparable to those of other pivotal studies.

Author(s): Sitthi Sukauichai, Chokaew Tovanabutra, Sirentra Wanglikitkul, Kittisak Chomprasert

Abstract Full Text PDF

Get the App

Bursa implant