Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1-504-608-2390

Research Article - Biomedical Research (2017) Volume 28, Issue 21

Study on CD4+CD25+Foxp3+T cells and clinical status of patients after renal transplantation

Objective: To investigate the ratio change rule and its clinical meanings of peripheral CD4+CD25+Foxp3+T cells of patients under various immune status after renal transplantation.

Methods: This study involved 59 patients receiving renal transplantation who were assigned into stable kidney function group (n=20), acute rejection group (n=23), and pulmonary infection group (n=16), selected 18 healthy volunteers in control group and tested the change of peripheral T cell subsets of all participants with flow cytometry.

Results: The proportion of peripheral CD4+CD25+T cells, CD4+Foxp3+T cells, and CD4+CD25+Foxp3+T cells of patients in stable kidney function group was much lower than that in control group, with a statistical difference (P<0.05), but higher than that in acute rejection group and pulmonary group in which the ratio of CD4+CD25+T cells also exceeded that in the healthy group, having a significant difference (P<0.05).

Conclusion: Carefully monitoring the change of peripheral regulatory T cells of patients who underwent renal transplantation plays an essential role in preventing and treating post-renal transplantation rejection and local infection.

Author(s): Bo Chen, Gai Hang, Yuan-Tao Wang, Zhi-Qiang Xu, Yu-Hong Feng, Chong-Sen Zang

Abstract Full Text PDF

Get the App

best replica reviews